The Yadkin Valley on the map for Wine

For years, when Winston-Salem was mentioned, the only thing that would come to mind is a pack of cigarettes. The iconic brand created by R. J. Reynolds in 1875 has all but disappeared and the new players in town include a bevy of wineries that are taking the area by storm.
Winston-Salem's wine region is the Yadkin Valley, which is less than an hour away. Currently, there are around 35 wineries/vineyards in the Valley. For over a hundred years, the area was a key tobacco-growing region. However, as tobacco farming and cigarette manufacturing started suffocating, some entrepreneurs, including tobacco farmers, turned to wine making. The irony is that up until a few years ago, the Yadkin Valley was a Dry County, so there were a few locals who were less than happy when the crushing parties came to town.
The native grapes of this region of the southeastern United States are the Muscadine and the Scuppernong. Say that ten times fast. Early attempts to grow the European wine grape, Vitis vinifera, in the southeastern United States, including 18th century efforts by Thomas Jefferson at Monticello, Virginia, didn't go so well. But in the past few decades, viticultural research has helped adapt these grapes to the climate, soil, and pests of the region. Now the area boasts an impressive lists of varietals.

In 2003, the United States' Bureau of Alcohol, Tobacco, Firearms and Explosives (love that combination) approved the new appellation for the region with the name Yadkin Valley AVA, allowing winemakers to bottle wines with labels indicating that the wine came from the Yadkin Valley. Now it's an official wine making region, the local teetotalers can't say much.